GLIA-CTN Career Development Award

Award Purpose: The GLIA-CTN Career Development Award is a mentored award designed to provide "protected time" for clinically trained individuals to receive supervised training in biomedical research related to leukodystrophies. A long-term goal is to establish a Leukodystrophy Center at each award recipient’s local institution. The award supports a period of supervised research, in conjunction with career development opportunities, for physician-scientists who require additional mentored training and support during development of an innovative research project.

Application Deadline: Applications must be received no later than February 20, 2023 (11:59PM EST).

Number of Awards: One GLIA-CTN Career Development Award will be awarded in FY23.      

Funding Period: Support will be provided for a one-year period.    

Level of Support: The GLIA-CTN Career Development Award will provide up to $85,000 for research and salary, inclusive of appropriate fringe and indirect costs. We recommend that the applicant ask for a waiver of indirect costs. No greater than 8% indirect costs are permitted. 

Eligibility Criteria: Candidates for the award must have a doctoral degree within the health professions (e.g., MD, DO, DDS, DMD, OD, DC, PharmD) and be actively affiliated with a US-based academic and/or health care institution. Individuals with degrees in nursing research and/or practice, who are licensed to practice clinically, may be eligible. There are also certain circumstances in which individuals with a PhD may be eligible, outlined below. 

Innovative, early-stage applications addressing key knowledge gaps that are without evidence of alternate means of funding (i.e., “high-risk/high-yield”) are encouraged. 

Eligible applications will meet the following key criteria.

  • The application must relate to a specific established leukodystrophy (see Vanderver et al., Mol Genet Metab. 2015; doi: 10.1016/j.ymgme.2015.01.006);
  • The application should include a preliminary feasibility assessment for the creation of a leukodystrophy center at the applicant’s institution. Preference will be given to applications that include an institutional letter of support to provide matching funding and resource allocation for the creation of such a center, including clinical care, diagnostic, and research resources that address the unique needs of patients with inherited white matter diseases;
  • The applicant must have adequate training to care for patients with leukodystrophy;
  • The application must include a pathway to additional funding or a subsequent career development award;
  • Although applicants must identify mentorship within the GLIA-CTN, co-mentorship beyond the GLIA-CTN will be permitted if appropriate to the scientific goals and academic development of the applicant;
  • The applicant must demonstrate willingness to collaborate with the GLIA-CTN in a sustainable way, including adoption of centralized/standardized data collection tools managed by the GLIA-CTN Data Integration Core (DIC);
  • The applicant must be within five years of completion of last training (i.e., last clinical or research fellowship);
  • Applicants holding a PhD only must demonstrate integration with the clinical team at their site, as well as partnership with clinicians to facilitate the establishment of a local Leukodystrophy Center.
  • The applicant must describe scientific methods that demonstrate adequate rigor and replication to translate the proposed research project into future clinical studies (i.e., description of alternative approaches or “Go/No-Go” criteria).
Applications should also meet the following feasibility criteria.

  • The applicant must demonstrate approval by their local Institutional Review Board (IRB) and, if appropriate, their Institutional Animal Care and Use Committees (IACUC) prior to accepting award funding. 
  • For pilot projects involving interventional approaches, the application must include a protocol synopsis and evidence of submission to appropriate regulatory bodies prior to submission.
International Applicants: At this time, only US-based investigators are eligible to apply for funding through a GLIA-CTN Career Development Award. We hope to be able to include international applicants in future award cycles. In the meantime, alternative funding mechanisms may be available to support international researchers interested in proposing either a new pilot project or collaborating on an existing project within one of the key disease areas outlined in Appendix A of the Request for Applications (RFA), available for download here. Please contact GLIA-CTN Program Manager, Omar Sherbini, MPH, at email@theglia.org for additional details.  

Institutional Commitment: Successful applications will include an institutional letter of support outlining matching funding and resource allocation for the creation of a Leukodystrophy Center. Please see Eligibility Criteria for details.    

Resource Utilization: Applications that include a plan to leverage central GLIA-CTN resources in one or more of the following ways will be prioritized:

  • Use of existing phenotype and longitudinal natural history previously collected through the consortium’s central repository, known as the Myelin Disorders Biorepository Project (MDBP);
  • Use of banked and/or prospectively collected biospecimen obtained by one or more clinical research centers currently participating in the GLIA-CTN;
  • Inclusion of one or more GLIA-CTN Principal and/or Site Investigators in project design and/or execution;
  • Inclusion of one or more GLIA-CTN Advocacy Committee Members/Organizations in project design and/or execution.
Reporting Requirements: Standard reporting requirements include the following.

  • A progress report will be expected at six (6) months following award, and a final report will be expected at twelve (12) months following award;
  • Funds will be disbursed at the end of each six-month reporting period;
  • Publication in the form of an abstract at a national or international meeting or submission of a manuscript for publication is expected within twelve (12) months of completion of the award;
  • The awardee is expected to attend, and be prepared to discuss their pilot project, at the GLIA-CTN Annual Instigator Meeting (Summer 2023), and attend the next GLIA Scientific Meeting (Spring 2024) after completion of their award.
Data Sharing Requirements: IRB/IACUC protocols must include language that permits protected health information (PHI) to be shared with the Children’s Hospital of Philadelphia (CHOP), and with the Rare Diseases Clinical Research Network (RDCRN) Data Management and Coordinating Center (DMCC) designated by the National Institutes of Health.

Suggested Application Structure: The GLIA-CTN Career Development Committee recommends the following application structure.

  • Pilot Proposal (2-3 Pages): Background, Innovation, Approach (inc. Specific Aims, Preliminary Data and Methods), Project Timeline, and Future Directions;
  • Career and Program Development (2 Pages): Candidate Background and Goals, Training Objectives, GLIA-CTN Mentor, Coursework and Seminars, Leukodystrophy Program Development, Program Structure, and Future Development;
  • Bibliography (1 Page)
Review Criteria: The following criteria will be considered during the review process.

  • Does the application meet the eligibility requirements?
  • Does the proposed research have the potential to improve care of patients?
  • Are the aims well defined?
  • Is the approach innovative?
  • Are the methods appropriate?
  • Will the collected data answer the stated aims? 
  • Is the budget adequate and the timeline realistic?
  • Is there strong institutional support for creation of a local Leukodystrophy Center?
Review Process: All applications will undergo the following two-stage process.

  • Applicants will submit a first-round application for review by the GLIA-CTN Career Development Committee. Feedback will be provided to all applicants.
  • Applicants with strong proposals will be invited to incorporate the Committee’s feedback and submit a revised application for a second round of review.
Disorders/Topics of Interest: Proposals focused on leukodystrophies with patient advocacy representation, listed in Appendix A of the Request for Applications (RFA), available for download here, will be given priority during the review process. Applicants interested in focusing on leukodystrophies not included on that list are encouraged to contact the GLIA-CTN Career Development Committee. 

Questions: Questions regarding the application requirements, submission guidelines, etc. may be directed to GLIA-CTN Program Manager, Omar Sherbini, MPH at email@theglia.org